Updated on June 11, 2:26 p.m. (GMT+8): Added the meaning of SAM.

Warning: Major spoilers if you haven’t played the quest “Gentleness, the Name of Nocturne” in Honkai Star Rail Trailblaze Mission “The Sound and the Fury”.

In Honkai Star Rail, Firefly appears as an outwardly sweet and ordinary girl. Unknown to many, she grapples with Entropy Loss Syndrome.

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In the first part of the Penacony Trailblaze Mission, Firefly shocks everyone by revealing a secret about her health and life amidst the captivating scenery of the Golden Hour — a moment that undoubtedly left a lasting impression on players.

But what exactly is Entropy Loss Syndrome? Join us as we delve into Firefly’s peculiar condition in Honkai Star Rail.

Entropy Loss Syndrome in Trailblaze Mission

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Entropy Loss Syndrome was first mentioned by the character Firefly in the Trailblaze Mission “The Sound and the Fury” in the act “Gentleness, the Name of Nocturne.”

In this quest, Firefly confesses to the Trailblazer in her “secret stronghold” at the border of Dream’s Edge dreamscape.

Entropy Loss Syndrome in Honkai Star Rail: What is Firefly’s illness in HSR?

This is how Firefly describes Entropy Loss Syndrome in the Trailblaze Mission:

It’s a strange condition. Those suffering from it will experience an irreversible chronic dissociation of their physical structure. This means they will slowly fade away, and the entire process is barely noticeable to others…

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You can still run, jump, and talk as usual. Everything seems normal, but then you’ll start doing everything slightly slower than others…

And then even slower than that, until the lines between your body and the entire world become blurry. You won’t be able to tell reality from dreams because they have all been shattered.

Firefly in Honkai Star Rail
Screenshot by Kristine Tuting/ONE Esports

In layman’s terms, Entropy Loss Syndrome is a fictional condition in Honkai Star Rail where people undergo a gradual and irreversible disconnection of their physical existence.

This means their bodies slowly fade away over time. At first, they might still be able to engage in everyday activities just like before. However, they’ll start doing things a bit slower than usual, progressively worsening.

Eventually, the distinction between their body and the surrounding world blurs, making it difficult to differentiate between reality and dreams due to the disintegration of their physical presence.

Entropy Loss Syndrome cause

Firefly’s affliction of Entropy Loss Syndrome is caused by “genetic modification,” according to a post by HoYoverse on X (formerly Twitter).

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Genetic modification is a process where the genetic material of an organism is altered in a way that does not occur naturally through mating or natural recombination. This manipulation can involve the insertion, deletion, or modification of specific genes within an organism’s DNA.

Entropy Loss Syndrome cure

It’s uncertain if there exists an Entropy Loss Syndrome cure at the time of writing.

In the narrative of Firefly, she finds herself confined in an “icy medical cabin” and diligently follows “all the doctor’s advice” for managing the condition.

What is the meaning of SAM in Honkai Star Rail?

It is later revealed in version 2.2 that the icy medical cabin Firefly is referring to is SAM, short for Strategic Assault Mech.

It is a Firefly Type-IV tactical heavy assault mech that belongs to the Iron Cavalry of Glamoth’s Firmament Frontline.

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